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Laveran (1896): "It should be insisted upon that in grave forms of malarial fever, and in the continual types of malarial fever one should not Google Digitized by April jo, 1898] purchase inderal USES AND LIMITATIONS OF NUCLEIN. 55i wait for the intermissions or even the remissions for the administration of quinin. " Laveran uses order inderal quinin by the mouth and hypodermically, preferring for the latter on account of inderal mg its solubility the chlorhydro- sulphate (5 grains of which can be easily dissolved in 15 minims of water). Dawson (1896): "The treatment of the different forms of malarial hematuria may vary somewhat as to detail, but our first effort should be to bring the patient as rapidly as possible under the influence of quinin in some form, so as to control the destructive power of the malarial germs, thereby holding the cause of the hemorrhage in abeyance, if not able to re- move it completely.' ' Dawson further states that he has used quinin in very large doses in malarial fevers, and has continued its use for long periods, and has never seen it produce hemoglobinuria. Tyson (1897) recommends quinin in malarial hematuria, and believes that this symptom is due cheap inderal to another cause than quinin. Anders (1897) says that he has observed several instances of hematuria in the milder forms of mala- ria in which no inderal price quinin had been taken and in which it had generic inderal subsequently been given (16 grains daily) with the result that the hemoglobinuria had been relieved. Since 1887, at the St. Louis Southwestern Rail- road Hospital of Tyler, Texas, several hundred cases of malarial fever have been annually treated. It is the routine practice there to administer inderal online quinin both in small and large doses (2 to 30 grains) by the mouth and hypodermically, as the case may de- mand, and it is not known that any case of hemoglo- binuria developed from its use. Further, since the buy cheap inderal year ending June 30, 1893, there were five cases of malarial hemoglobinuria admitted inderal tablets to the wards — in all of which the patients received quinin; in no case was the condition made worse by quinin, and all of the patients recovered. THE USES AND LIMITATIONS OF NUCLEIN ASA THERAPEUTIC AGENT. By J. H. BURCH, M.D., OF online propranolol BALDWINSVILLB, N. Y. Perhaps nothing can demonstrate more fully the heterogeneous tendency of the medical thought of our age, than a careful perusal of current litera- ture upon the action and uses of nuclein. While a few patient and careful observers like Vaughn, Metchnikoff, and Ames are earnestly working to demonstrate its sphere of usefulness as a therapeutic agent, scores of others, with no guide or aim than that of the grossest empiricism, are extolling its ap- plication in the most diversified and conflicting con- ditions. I well remember the hopes which some of these gushing opinions inspired in me, and the sev- eral failures which resulted from my early exhibitions of this agent, but, although I buy propranolol had several startling failures, I was often rewarded with signal success, and it was a careful review of these several successes and failures which led me to believe that nuclein, like every other remedial agent, has it uses purchase propranolol online circumscribed by clear-cut limitations. In this connection, I re- cord the following case: Case I. — Mrs. S., aged forty-nine years, came to me presenting the appearance of an emaciated, over- worked woman. She was the mother of seven chil- dren purchase inderal online born in rapid succession. She had always at- tended to her household duties, working from early in buy inderal the morning until late at night. While her fam- ily and personal history were all that could be buy inderal online desired, her sunken eyes, anemic and pinched face, bloodless lips, cold hands, and irregular heart-action, with its hemic murmur, all bespoke the impoverished con- dition of her blood. I examined her urine, and found that she daily passed propranolol hydrochloride 80 mg for anxiety about 1500 c.c. of urine, which was pale and clear with no other abnormality than that the phosphates were increased to sixteen per cent. Examination of the blood revealed the red corpuscles reduced to 3,200,000 order inderal online to the cm. (Thoma-Zeiss), poikylocytosis well marked, the red cells taking the stain badly (Ehrlricke), and leaving round hyaline spaces within the corpuscles. There were no nucleated red cells or other abnormal cell formation; hemoglobin seventy- inderal cost five per cent.; the number of leucocytes was 8400 to the cm., and they were normal in every respect, except, perhaps, a slight increase in the number of eosinophiles. With purchase propranolol this history and clinical finding I prescribed nuclein, with the result that I allowed this poor woman to remain six weeks in this condition, carefully ex- amining her blood three times weekly, with no other result than a marked leucocytosis which in no way re- lieved the anemia. A six- weeks' course of iron and arsenic almost completely restored her health.

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